Dr. Emmanuel S. Antonarakis, M.D.

Dr Antonarakis is the Clark Endowed Professor of Medicine and Director of Genitourinary Oncology in the Division of Hematology/Oncology and Transplantation at the University of Minnesota. He also serves as the Associate Director for Translational Research at the Masonic Cancer Center.

Previously he was Professor of Oncology and Urology at the Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, the Director of Prostate Cancer Medical Oncology Research, and the Co-Director of the Prostate Cancer Multi-Disciplinary Clinic at Johns Hopkins.

Dr Antonarakis an expert on the clinical management of advanced prostate cancer and other genitourinary malignancies. He has received numerous awards for his translational research and his teaching skills.

He is involved in mentoring fellows and junior faculty in the clinical care of genitourinary cancers and the development of translational clinical trials related to prostate cancer.

Dr Antonarakis’ research focuses on drug development and clinical trial design for patients with prostate cancer, as well as cancer genetics and genomics. More specifically, he is exploring novel androgen-directed therapies, genetically targeted therapies, and immunotherapies for men with recurrent or advanced prostate cancer, using germline and cancer genomics to inform precision oncology approaches.

He also has an interest in liquid biomarker development, specifically the clinical utility of the AR-V7 marker as well as DNA repair markers and their therapeutic implications. He is the PI of multiple phase II and III prostate cancer trials and is an active member of the Prostate Cancer Clinical Trials Consortium (PCCTC) and the ECOG-ACRIN and Alliance Cooperative Groups, as well as the NCI Prostate Cancer Task Force and the NCCN Prostate Cancer Panel.

In 2021, he was elected into the American Society for Clinical Investigation (ASCI). He serves on the Editorial Board of several oncology journals, including the Journal of Clinical Oncology.

He is the author of over 410 peer-reviewed scientific articles, several book chapters, and has edited two textbooks on prostate cancer.